Improved scFv Anti-LOX-1 Binding Activity by Fusion with LOX-1-Binding Peptides

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Improved scFv Anti-LOX-1 Binding Activity by Fusion with LOX-1-Binding Peptides

The oxidized low-density lipoprotein receptor-1 (LOX-1) targeted single-chain variable fragment (scFvs) is a promising molecule for the targeted delivery of imaging and therapeutic molecules of atherosclerotic diseases; however, its applications are limited by the inherent low antigen affinity. In this study, the three-dimensional (3D) model of the anti-LOX-1 scFv was constructed and its dockin...

متن کامل

LOX-1 boosts immunity

Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is a class E scavenger receptor that is encoded by the OLR1 gene on human chromosome 12. LOX-1 is expressed as a type II transmembrane protein containing four domains: an extracellular C-terminal lectin domain, a connecting neck domain, a single transcellular domain and a short N-terminal cytoplasmic tail. A disulfide bond be...

متن کامل

LOX-1 protein, A Biomarker in the Prognosis of Atherosclerosis

LOX-1 is a class E scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved in endothelial dysfunctions, monocyte adhesion, the proliferation, migration, and apoptosis of smooth muscle cells, foam cell formation, platelet activation, as well as plaque instability; all of these events are critical in the pathogenesis of atherosclerosis. These LOX-1-dependent bio...

متن کامل

LOX-1 in Ischemic Stroke

LOX-1, an OLR1 gene product, has been found to be the receptor for oxidized low density lipoprotein (LDL) to induce endothelial dysfunction. Animal studies suggested that LOX-1 promotes atherosclerosis, aggravates myocardial infarction, and enhances restenosis. Although researchers have mainly focused on coronary artery disease, reports on ischemic stroke are gradually accumulating. In parallel...

متن کامل

LOX-1, OxLDL, and Atherosclerosis

Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation. Vascular wall cells express on their surface several scavenger receptors that mediate the cellular effects of...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: BioMed Research International

سال: 2017

ISSN: 2314-6133,2314-6141

DOI: 10.1155/2017/8946935